Serine peptidase inhibitor Kazal type 2 gene expression level in de novo acute myeloid leukemia patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective This study aimed to evaluate serine peptidase inhibitor Kazal type 2 (SPINK2). Nowadays, gene expression of acute myeloid leukemia (AML) in relation to disease characteristics and response to induction chemotherapy Patients and methods The study was performed on 40 AML patients and 40 healthy controls. Detection of SPINK2 gene expression in peripheral blood was performed by RNA extraction, reverse transcription, and real-time PCR at the Hematology Department, Medical Research Institute, Alexandria University. Results We have demonstrated that the SPINK2 gene was significantly overexpressed in AML patients compared with normal controls. Conclusion SPINK2 gene expression was significantly overexpressed in AML patients. It is possible that SPINK2 can serve as a biomarker for AML diagnosis and prognosis.
Authors: Sarah M. Nawar, Asmaa Mahmoud
Institution: Alexandria University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413383659