Work

Rucaparib-Associated Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome

Year: 2025

Type: article

Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially severe reaction to certain drugs. The use of poly (ADP-ribose) polymerase (PARP) inhibitors such as rucaparib has improved the management of several solid tumor types. We present a case of a 63-year-old woman who developed DRESS syndrome potentially after rucaparib and presented with fever, rash, eosinophilia, and elevated liver enzymes. The patient's symptoms resolved with systemic and topical steroids without any associated sequela.

Source: Cureus

DOI: 10.7759/cureus.90619

Authors: Steven Ludlow, Bushra Shariff, Misbahuddin Syed

Institution: Moffitt Cancer Center

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413385185