Work

Achieving a rapid and continuous learning health system requires socio-technical harmonization of research and operational IT

Year: 2025

Type: review

Abstract: This perspective identifies challenges in integrating clinical research and care delivery in a rapid and continuous Learning Health System (LHS), focusing on Information technology (IT) systems and workforce harmonization. Based on our experiences, we analyzed differences in funding mechanisms, governance, regulatory frameworks, priorities, workforce culture, technology architecture, risk tolerance, and data standardization. We highlight significant barriers to the LHS implementation caused by IT misalignment between clinical research and patient care and propose strategies to overcome these challenges.

Source: npj Health Systems

DOI: 10.1038/s44401-025-00031-6

Authors: Cong Liu, Casey N. Ta, Elisabeth S. DiMaria, Rachel C. Shelton, Karthik Natarajan, Soumitra Sengupta, James J. Cimino, Chunhua Weng

Institutions: Boston Children's Hospital, Columbia University, University of Alabama at Birmingham

Language: English

Topic: Electronic Health Records Systems

Subfield: Health Information Management

Field: Health Professions

Domain: Health Sciences

SDGs: Good health and well-being, Industry, innovation and infrastructure

Open Access status: gold

Estimated APC paid: $2,790

Funders: National Institutes of Health, National Human Genome Research Institute, U.S. National Library of Medicine, National Center for Advancing Translational Sciences

Awards: Deep phenotyping in Electronic Health Records for Genomic Medicine, EHR-based Genomic Risk Assessment and Management for Diverse Populations, Big Data Methods for Comprehensive Similarity based Risk Prediction, RESCUE: Rare Disease Detection and Escalation Support via a Learning Health System, Clinical and Translational Science Award, Fair Phenotype Annotation and Genomic Reinterpretation

OpenAlex ID: W4413400183

FWCI: 0.485

Cites: 31

Cited by: 6

Related to: 10