Mechanisms of lung crosstalk with end organs: scientific session V—ReSPIRE 2025
Year: 2025
Type: review
Abstract: Session V of the inaugural biennial Research Symposium on Pulmonary Injury and Repair of the Endothelium showcased cutting-edge research on pulmonary endothelial crosstalk with end organs and its role in vascular disease. Growing evidence suggests that communication between injured organs and distal vascular beds plays a critical role in the pathogenesis of complex conditions such as sepsis, acute respiratory distress syndrome, pulmonary arterial hypertension, and heart failure with preserved ejection fraction. Circulating mediators-including heparan sulfate fragments, proinflammatory cytokines, mitochondrial damage-associated molecular patterns, bone morphogenetic protein 9, bile acids, and nitric oxide-have emerged as key factors linking pulmonary endothelial dysfunction to neural impairment, acute kidney injury, subclinical liver injury, and left-sided heart disease. This review highlights recent advances in the field, identifies critical knowledge gaps, and outlines future research directions aimed at elucidating mechanisms of multiorgan dysfunction and identifying novel therapeutic targets.
Institutions: Brown University, Humboldt-Universität zu Berlin, German Centre for Cardiovascular Research, Freie Universität Berlin, Charité – Universitätsmedizin Berlin, Harvard University, Mass General Brigham, University of California San Diego, VA San Diego Healthcare System, University of California, San Francisco, University of South Alabama
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, American Thoracic Society, Deutsche Forschungsgemeinschaft, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: SFB 1470: Mechanistische Charakterisierung von Herzinsuffizienz mit erhaltener Auswurffraktion durch tiefe Phänotypisierung Etablierung einer neuen Klassifizierung von HFpEF für gezielte TherapieAnsätze, MESENCHYMAL STEM CELLS FOR TREATMENT OF ARDS FOLLOWING TRAUMA, Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsis, Mucosal Immune Barrier in Infection and Immunity, 1/1: ARREST RESPIRATORY FAILURE DUE TO PNEUMONIA (ARREST PNEUMONIA), The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock, G7364485362, G804212192, Lung Endothelial Aß in infectious proteinopathy, Cellular and molecular mapping of ventilator-induced lung injury, Mechanisms of acute kidney injury due to mechanical ventilation, Soluble adenylyl cyclases in lung endothelial tauopathy, Vascular mechanisms of sepsis-induced cognitive dysfunction
OpenAlex ID: W4413409196