Work

Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature

Year: 2025

Type: article

Abstract: Hepatosplenic T-cell lymphoma (HSTL) is a rare and aggressive mature T-cell lymphoma characterized by hepatosplenic involvement. It usually occurs de novo in adolescents and young adults (AYA) and has been most commonly reported in the setting of immunosuppression. Most cases present with proliferation of cytotoxic T-cells of TCRγδ type with a unique gene mutation profile. Due to rarity of this disease, there is no standard of care treatment, and outcomes are usually poor in the absence of stem cell transplant. In this case, we report an unusual presentation of HSTL of TCRαβ type in an elderly patient status post treatment of an indolent B-cell lymphoma.

Source: Human Pathology Reports

DOI: 10.1016/j.hpr.2025.300789

Authors: Rodolfo Garza-Morales, Isabela Wen-Chi Chang, Allison Rosenthal, Jiehao Zhou

Institutions: Mayo Clinic, Mayo Clinic Hospital

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160