Year: 2025
Type: article
Abstract: The application of conductive polymers in wound dressings presents great potential for accelerated wound healing since their high electrical conductivity and biocompatibility facilitate the delivery of external electrical stimuli to cells and tissues, promoting cell differentiation and proliferation. Electrospinning is a very straightforward method for the preparation of polymeric wound dressings capable of mimicking the extracellular matrix of skin, promoting hemostasis, absorbing wound exudate, allowing atmospheric oxygen permeation and maintaining an appropriately moist environment. In this work, in situ chemically polymerized poly(3,4-ethylenedioxythiophene) (PEDOT) was achieved through hyaluronic acid-doping. The synthesized PEDOT was used for the production of conductive and biodegradable chitosan (CS)/gelatin (GEL)/PEDOT electrospun meshes. Additionally, the randomly aligned meshes were crosslinked with a 1,4-butanediol diglycidyl ether and their physicochemical and mechanical properties were investigated. The results show that the incorporation of a conductive polymer led to an increase in conductivity of the solution, density and fiber diameter that influenced porosity, water uptake, and dissolvability and biodegradability of the meshes, while maintaining appropriate water vapor permeation values. Due to their intrinsic similarity to the extracellular matrix and cell-binding sequences, CS/GEL/PEDOT electrospun nanofibrous meshes show potential as conductive nanofibrous structures for electrostimulated wound dressings in skin tissue engineering applications.
Source: Polymers
Authors: Alexandra I. F. Alves, Nuno M. Alves, Juliana R. Dias
Institution: Universidade de Leiria e Oeste
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,258
Awards: G1186763055, G1584003897, G2058374498, G2225939727, G3025221457, G3375258393, G3458087112, G3507939551, Centro para o Desenvolvimento Rápido e Sustentado de Produto, G4602034491, G463812321, G5618015209, G6112469143, Untitled, G6869800521, G6997658380, Centro para o Desenvolvimento Rápido e Sustentado de Produto, Produção Avançada e Sistemas Inteligentes, G8965991992
OpenAlex ID: W4413416876