Ventriculoperitoneal shunt outcomes in neurodegenerative normal pressure hydrocephalus: A case series of 29 patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Management of normal pressure hydrocephalus (NPH) can be complicated by the progression of underlying neurological conditions such as Alzheimer's disease or Parkinson's disease. The purpose of this study is to explore the long-term shunting response on gait dysfunction in patients with neurodegenerative NPH, a subtype of NPH occurring in patients with another neurodegenerative condition, as the duration of symptomatic improvement with shunting is unclear in this population. Methods: A retrospective chart review of patients undergoing evaluation for NPH at the Adult Hydrocephalus Center at Allegheny General Hospital was performed. Timed performances on two gait measures, the timed walk and timed up and go, were collected during a 2-day outpatient lumbar tap trial and on follow-up evaluation after shunt placement. Improvements over baseline were calculated at each follow-up and analyzed by years after shunt surgery. Potential sequelae of VPS such as subdural hematomas and infection during the study period were tallied. Results: year after surgery through the remainder of the study period. Conclusion: While VPS can provide a limited period of improved gait, it was not shown that shunting can provide persisting benefit in patients with underlying progressive neurodegenerative disease. Shunting to alleviate gait symptoms should be considered on a case-by-case basis with patients and their families in alignment with care goals.
Source: Surgical Neurology International
Authors: Ethan James Richman, Sanjiv Harikumar, Ian Lonich, Timothy Leichliter, Praveer Vyas, Jody Leonardo
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4413417007