Work

The Influence of the Type of Metal-on-Metal Hip Endoprosthesis on the Clinical, Biochemical, and Oxidative Balance Status—A Comparison of Resurfacing and Metaphyseal Implants

Year: 2025

Type: article

Abstract: Introduction: Despite the increasingly rare use of metal-on-metal articulation, in many countries, there is a large group of patients after hip arthroplasty using this method. The operation of the dysfunctional hip joint using metal-on-metal articulation can be performed by resurfacing or total, stemmed arthroplasty. The aim of this study was to compare the metaphyseal and resurfacing methods in metal-on-metal articulation and its impact on clinical status and variability of oxidative stress parameters, as well as the concentration of chromium and cobalt ions in blood. Materials and methods: The first group operated using BHR (Smith & Nephew) and Biomet ReCap-Magnum metal-on-metal hip resurfacing implants. The second group operated using Biomet ReCap-Magnum with a Microplasty metaphyseal stem. Two clinical evaluations were conducted in each patient with the use of SF-12, HHS, and WOMAC-hip examination scale systems. The concentrations of metal ions in blood and their impacts on the antioxidant system were also determined twice using various oxidative stress markers. Results: The study included 61 males. The mean values of the Cr (p = 0.019) and Co (p = 0.009) ion concentrations were higher in patients after resurfacing arthroplasty. A higher intensity of oxidative stress (activities of sulphydryl groups, malondialdehyde, and lipofuscin) was observed in the resurfacing group compared with the metaphyseal group. Conclusions: The resurfacing hip implant in the metal-on-metal articulation, to a greater extent than the metaphyseal one, elevates the concentration of Cr and Co ions in the blood and is associated with oxidative stress and the functioning of the antioxidant system.

Source: Nanomaterials

DOI: 10.3390/nano15161258