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From Clinical Suspicion to Therapeutic Resolution: A Case of Melkersson-Rosenthal Syndrome

Year: 2025

Type: article

Abstract: Melkersson-Rosenthal syndrome (MRS) is a rare, chronic condition characterized by orofacial edema, facial paralysis, and fissured tongue. Its etiology remains unclear, although genetic, immunological, and infectious factors have been proposed in its pathogenesis. Various treatment modalities have been suggested, including corticosteroids, antibiotics, immunosuppressants, and, in severe cases, surgical intervention. Early identification is essential to improve prognosis and prevent complications. We report the case of a 33-year-old woman presenting with progressive and persistent oral edema accompanied by a fissured tongue. Histopathological examination confirmed granulomatous cheilitis, leading to the diagnosis of MRS. Treatment with intralesional triamcinolone acetonide and doxycycline was initiated, resulting in an excellent clinical response.

Source: Cureus

DOI: 10.7759/cureus.90763

Authors: Omar Gerardo Galaviz-Chaparro, José Alfredo Soto-Ortiz, Claudia Velázquez-Rodríguez, Andrea Sierra-Franco, María Fernanda Limón-Limón

Institution: Universidad de Guadalajara

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413425391