Work

Population pharmacokinetic analysis of letermovir in adult hematopoietic cell transplant recipients

Year: 2025

Type: article

Abstract: We analyzed previously reported oral letermovir plasma concentration measurements from 40 allogeneic hematopoietic cell transplant (HCT) recipients using model-based pharmacometrics analysis. This analysis highlighted that the industry-sponsored phase III study model significantly over-predicted observed letermovir concentrations. Covariates associated with increased oral clearance (CL/F), possibly contributing to this observation, included: higher weight, younger age, and early use after HCT. The clinical significance and mechanistic explanation of relatively lower real-world exposure remains to be elucidated.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00697-25

Authors: Léna Royston, Carla Kunz, David Tonoli, Pierre Lescuyer, Dionysios Neofytos, Verena Gotta

Institutions: University Hospital of Geneva, University of Basel, University Children’s Hospital Basel

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond