Early recurrence of olfactory neuroblastoma: A case report and literature review
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Olfactory neuroblastoma (ONB) is a rare malignant tumor of the sinonasal cavity, often presenting with nonspecific symptoms and requiring complex multidisciplinary management. Case Description: A 55-year-old male developed progressive anosmia and recurrent epistaxis. Imaging revealed an invasive lesion involving the nasal cavity, paranasal sinuses, and intracranial space, along with cervical lymph node metastases. Diagnosis was confirmed histologically. Patient underwent craniofacial approach, cervical lymphadenectomy, and adjuvant radiotherapy. Despite aggressive treatment, early recurrence occurred in both nasal and intracranial compartments. With curative options exhausted, the patient was transitioned to palliative care. Conclusion: ONB has a high risk of recurrence, typically occurring years after initial treatment. However, early recurrence, as seen in this case, is rare and associated with aggressive tumor features such as high-grade histology and incomplete resection. These cases present significant therapeutic challenges and underscore the importance of close surveillance and further research into optimal management strategies for early recurrent ONB.
Source: Surgical Neurology International
Authors: Alex Roman, Moisés Augusto de Araújo, Rudolfh Batista Arend, Bruno Zilli Peroni, Daniel Felipe Savaris, Renata dos Santos Rabello, Victor Luiz Ferreira Kauer, Filipe Virgilio Ribeiro
Institution: Universidade Federal da Fronteira Sul
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4413431913