Year: 2025
Type: article
Abstract: INTRODUCTION: The pineal gland (epiphysis cerebri) plays a central role in the circadian system, partnering with the eyes and the suprachiasmatic nuclei of the hypothalamus. It secretes melatonin in response to the light-dark cycle, regulating various body rhythms, particularly the sleep-wake cycle. SIGNIFICANCE: Melatonin's rhythmic secretion is crucial for synchronizing internal physiology with environmental changes. Understanding its role helps address sleep disorders, mood disturbances, and reproductive issues, and informs therapies related to circadian rhythm disruptions. METHODOLOGY: A review-based analysis was conducted using published literature on pineal physiology, melatonin secretion patterns, and light-induced changes. Comparative data from both diurnal and seasonal animals were examined to evaluate functional significance. RESULTS: • Melatonin levels are high at night and suppressed by light. • Secretion persists in darkness, indicating endogenous control. • Light exposure at night reduces melatonin acutely. • Seasonal variation affects melatonin duration and influences reproduction and thermoregulation in animals. DISCUSSION: The pineal gland functions as a photoneuroendocrine transducer, translating light input into hormonal output. Its regulation of melatonin plays a critical role in circadian alignment and seasonal adaptation. Disruption in melatonin rhythms is linked to sleep disorders and altered physiological states. CONCLUSION: The pineal gland, via melatonin, is essential for circadian and seasonal regulation. Its sensitivity to light and rhythmic secretion pattern make it a cornerstone of internal biological timing, with broad implications for health and adaptive behavior.
Authors: Don Berin G, J Ashok
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4413434884