Work

Discovery of a Novel Series of iso -Indolinone-Based Glutarimides as Highly Efficacious and Selective IKZF2 Molecular Glue Degraders

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00668

Authors: Xuqing Zhang, Harshil Dhruv, Qiaolin Deng, Matthew Tudor, Nelisa Bechtel, Rakesh Nagilla, Larry Jolivette, Cory T. Rice, Peter Orth, Elham Behshad, Corey Strickland, Helai P. Mohammad, Longchuan Bai, Donna McEachern, Shaomeng Wang, Zhihua Sui, E. Scott Priestley

Institutions: SK Group (South Korea), University of Michigan, U-M Rogel Cancer Center

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W4413435133

FWCI: 2.039

Cites: 54

Cited by: 8

Related to: 10