Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections for Glycemic Management in Pregnant Women With Type 1 Diabetes: A Systematic Review and Meta-Analysis
Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Background/Objective: To compare glycemic management outcomes between continuous subcutaneous insulin infusion (CSII) and multiple daily injections in pregnancy and assess maternal and neonatal outcomes. There is an ongoing increase in diabetes rates worldwide. The International Diabetes Federation estimated that there were 23.0 million cases of hyperglycemia (19.7%) before and during pregnancy in 2024 worldwide, causing 1.5 million deaths annually. Pregnant women with pregestational type 1 diabetes mellitus (T1DM) struggle with 2-4 times more maternal and fetal complications than pregnant women without diabetes. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed MEDLINE, Cochrane, Scopus, Web of Science, Embase, Cumulative Index to Nursing and Allied Health Literature, and China National Knowledge Infrastructure through January 2025. Eligible studies included randomized controlled trials, cohort studies, and case-control studies comparing CSII and multiple daily injection in pregnant women with T1DM. Data were pooled using random-effects models, with effect sizes expressed as mean differences (MDs), standardized mean differences, or risk ratios (RRs) with 95% CIs. Results: Thirty-one studies encompassing 6532 pregnant women were included. CSII was associated with improved glycosylated hemoglobin control in the first (MD, -0.34; 95% CI, -0.49 to -0.18) and second trimesters (MD, -0.15; 95% CI, -0.29 to -0.01), alongside reduced insulin requirements in early pregnancy (standardized mean difference, -0.43; 95% CI, -0.61 to -0.24). However, CSII was also linked to increased risks of cesarean delivery (RR, 1.11; 95% CI, 1.04-1.18), neonatal hypoglycemia (RR, 1.15; 95% CI, 1.03-1.30), and large-for-gestational-age infants (RR, 1.22; 95% CI, 1.11-1.34). No consistent differences were observed for preeclampsia, congenital malformations, or preterm birth. Heterogeneity across outcomes was moderate to high, reflecting variation in study design and quality. Conclusion: CSII offers measurable metabolic advantages during pregnancy by lowering glycosylated hemoglobin levels and reducing insulin needs. Nevertheless, these benefits do not consistently translate into improved maternal or neonatal outcomes and may be offset by higher obstetric and neonatal complication rates. Further well-powered randomized controlled trials are required to clarify the role of CSII and to balance metabolic gains against obstetric risks in managing pregnant women with T1DM.
Source: AACE Endocrinology and Diabetes
Authors: Angie Carolina Alonso Ramírez, Jonathan Víctor Salazar Ore, Olivia Murga, Stephani Carolina Salvatierra Moreno, Hugo Lana Devita, Maigualida Nieto, Jobby John, Loura Aly, Gabriela D. Briceno Silva, Stephin Zachariah Saji, Victor Sebastian Arruarana, Ricardo Correa Marquez, Ernesto Calderón Martinez
Institutions: Pontificia Universidad Javeriana, Universidad de Buenos Aires, Universidad de Los Andes, Universidad Central de Venezuela, Dr. Somervell Memorial CSI Medical College and Hospital, Ilia State University, Universidad de Oriente, Our Lady of Fatima University, Brookdale University Hospital and Medical Center, Cleveland Clinic, The University of Texas Health Science Center at Houston
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413439326