Work

Petri net on expanded networks computes the dynamics of finite multilevel models

Year: 2025

Type: article

Abstract: We discuss connections between different types of models of gene-regulatory network dynamics that include Boolean, finite multilevel and monotone Boolean models. We recast the methodology of describing attractors of Boolean and finite multilevel dynamics using motifs of the expanded network e R N in terms of Petri net dynamics on e R N . We show that the Petri net can be used to recover dynamics of the finite multilevel dynamics on the state transition graph. We conclude with new insights that the expanded network viewpoint offers for the robustness of equilibria and complex attractors.

Source: Interface Focus

DOI: 10.1098/rsfs.2024.0059

Authors: Elizabeth Andreas, Eli Quist, Tomas Gedeon

Institutions: Montana State University, U.S. Air Force Research Laboratory Information Directorate

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4413440865

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Cites: 70

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Related to: 10