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Acute generalized exanthematous pustulosis induced by flupentixol-melitracen: a previously unreported drug reaction

Year: 2025

Type: article

Abstract: Acute generalized exanthematous pustulosis (AGEP) is a rare and severe cutaneous drug reaction, most often triggered by antibiotics or antifungals. Psychotropic medications are an uncommon cause. We report the case of a 60-year-old male who developed AGEP within 24-48 hours of initiating flupentixol-melitracen, a fixed-dose antipsychotic-antidepressant combination. Clinical features included widespread sterile pustules on an erythematous base, and histopathology confirmed the diagnosis. The eruption resolved rapidly upon drug withdrawal and topical corticosteroids. To the best of our knowledge, this is the first reported case of AGEP induced by flupentixol-melitracen. Clinicians should consider this rare association when evaluating drug-induced pustular eruptions.

Source: International Journal of Basic & Clinical Pharmacology

DOI: 10.18203/2319-2003.ijbcp20252588

Authors: Dipanjan Das, Lairenjam Teza, Asok Gangopadhyay

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413441277

FWCI:

Cites: 3

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Related to: 10