Work

Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments

Year: 2025

Type: article

Abstract: The microenvironments play a crucial role in secondary injury following spinal cord injury (SCI). Deterioration of the microenvironments, including oxidative stress, inflammation, and excitotoxicity, exacerbates SCI. However, due to the complexity of these microenvironments, synergistic modulation of multiple factors remains challenging. In this study, we developed a reactive oxygen species (ROS) responsive nanoformulation system based on a methoxy poly(ethylene glycol)- block -poly(L-methionine- co -L-glutamic acid) copolymer (PME) and loaded it with minocycline (PME@Mino) to promote SCI repair. This nanoformulation was administered intravenously, accumulating at the lesion site where PME@Mino was exposed to ROS, triggering the release of minocycline. Through the synergistic modulation of multiple microenvironment factors,including reduction of oxidative stress, regulation of pro-inflammatory M1 macrophages polarization to anti-inflammatory M2 macrophages, and reduction of calcium ion influx,PME@Mino achieved neuronal and myelin protection. This study highlights advanced approaches for modulating microenvironments using nanoscale treatments for SCI.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2025.102227

Authors: Yuehong Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu

Institutions: Jilin University, First Hospital of Jilin University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400