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Effects of Antimicrobial Photodynamic Therapy Mediated by Methylene Blue and Prototype Equipment for Irradiation of Acrylic Resin Prosthetic Devices

Year: 2025

Type: preprint

Abstract: This study evaluated the antimicrobial effect and technical feasibility of photodynamic therapy (PDT) mediated by the photosensitizer methylene blue at 22 μM and irradiation using a prototype device with eight 630 nm, 1 W light-emitting diodes (LEDs), targeting contamination present in acrylic dentures before installation. PDT reduced viable bacteria (p = 0.0002) compared to the irradiated group and reduced viable fungi compared to the untreated and irradiated groups (p = 0.0002). The most prevalent bacteria identified were P. aeruginosa , K. pneumoniae , and E. coli , and PDT significantly decreased their counts (p < 0.001), with an effect similar to chlorhexidine (p > 0.05). The proposed PDT protocol for acrylic resin devices demonstrated promising antimicrobial effects and technical feasibility.

DOI: 10.22541/au.175543044.47393956/v1

Authors: Janaína Câncio de Holanda Prado, Davi Valentim Oliveira, Amanda de Menezes Porto, Matheus Loíky Sampaio de Souza, Thyciana Rodrigues Ribeiro, Bruna Marjorie Dias Frota de Carvalho, Bruna Albuquerque Garcia, Karina Matthes de Freitas Pontes

Institutions: Universidade Federal do Ceará, University of Florida Health, University of Florida

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4413450676

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