Work

Therapeutic Challenges in the Use of Chemotherapy and Cyclin-Dependent Kinase 4/6 Inhibitors in a Patient With Charcot-Marie-Tooth Disease and Breast Cancer

Year: 2025

Type: article

Abstract: We report a rare clinical scenario involving a 65-year-old female patient with Charcot-Marie-Tooth (CMT) disease who was diagnosed with early-stage breast carcinoma. The patient underwent neoadjuvant chemotherapy, followed by surgery and adjuvant endocrine therapy. During treatment, she developed grade 3 peripheral neuropathy, leading to the early discontinuation of paclitaxel and subsequent therapeutic adjustments. This report highlights the challenges of managing patients with neuromuscular comorbidities undergoing chemotherapy and the use of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors as adjuvant therapy in breast cancer treatment.

Source: Cureus

DOI: 10.7759/cureus.90239

Authors: Pedro Mota Araújo, Renato Cunha, Marta Sousa

Institution: Unidade Local de Saúde de Trás-os-Montes e Alto Douro

Language: English

Topic: Cancer Treatment and Pharmacology

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413452314