Sonographic-assisted evaluation and elemental-crystalline characterization of a dual-responsive chitosan hydrogel loaded with eupatorium odoratum for advanced wound therapy
Year: 2025
Type: article
Abstract: This study presents the formulation and evaluation of a dual-responsive (pH and temperature-sensitive) chitosan hydrogel encapsulating Eupatorium odoratum extract, intended for enhanced wound healing. Elemental analysis using Energy Dispersive X-ray Spectroscopy (EDX) confirmed the uniform distribution of encapsulated actives. EDX revealed significant presence of C, O, and N, indicative of chitosan and plant bioactives. Sonographic imaging demonstrated the controlled hydrogel release behavior in simulated soft tissue, with grayscale intensity decreasing from 62.1 (0 min) to 20.2 (4 hrs), confirming diffusion dynamics. Thermogravimetric Analysis (TGA) assessed the thermal stability and decomposition pattern of the hydrogel. These findings support the potential of integrating sonography, EDX, and TGA for evaluating nanostructured wound healing systems.
Authors: Sylvia Ifeyinwa Okonkwo, Rita Ebele Emendu, Charles Kenechukwu Okonkwo, Vera Obiageli Ezigbo, Emmanuella Chinyere Okafor, Peter Obinna Okwuego, Adachukwu Theresa Kene-Okonkwo, Valentine Somtochukwu Okonkwo
Institutions: Chukwuemeka Odumegwu Ojukwu University, Tansian University
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413460322