Work

Cavitating Mesenteric Lymph Node Syndrome With Autoimmune Pancreatitis and Hepatitis: A Case Report and Literature Review

Year: 2025

Type: article

Abstract: Cavitating mesenteric lymph node syndrome (CMLNS) is a rare and severe complication of refractory celiac disease. It is characterized by the triad of cavitating mesenteric lymph nodes, splenic atrophy and villous atrophy of the small bowel mucosa. We present the case of a 36-year-old male patient with a known diagnosis of celiac disease who presented with fever and diarrhea. Further evaluation revealed progression to refractory celiac disease and he developed the rare complication of CMLNS along with concomitant autoimmune hepatitis and autoimmune pancreatitis. We concluded from our case that despite adherence to a strict gluten-free diet and high-dose corticosteroids, cavitary mesenteric lymph node syndrome is highly fatal and leads to complications like septic shock and gastrointestinal perforation. We emphasize the critical need for early recognition of refractory celiac disease and highlight the potential of associated autoimmune disorders, which significantly complicate patient management. Timely diagnosis of complications such as autoimmune pancreatitis and hepatitis is crucial, as they necessitate distinct therapeutic approaches. Our case underlines the urgency of developing more effective treatment strategies to improve patient outcomes.

Source: Cureus

DOI: 10.7759/cureus.90183

Authors: Aoumar Chama, Wendy Saliba, Anthony Nasr

Institutions: University of Balamand, Lebanese University

Language: English

Topic: Celiac Disease Research and Management

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413464372