Work

Cancer-associated Fibroblasts Confer Osimertinib Resistance in Non-small Cell Lung Cancer Cells via NRG1-mediated HER3/AKT Signaling

Year: 2025

Type: article

Abstract: . Our finding highlights the potential value of CAFs-derived NRG1 as a novel therapeutic target for osimertinib resistance in lung cancer.

Source: Journal of Cancer

DOI: 10.7150/jca.111383

Authors: Sijia Zheng, Limin Cao, Jiayi Zhang, Qicheng Zhang, Yinghui Ren, Min Wang, Yongmei Qian, Bingbing Li, Xiang Wu, Zhaowei Meng, Ke Xu

Institutions: Tianjin Medical University General Hospital, Tianjin Children's Hospital, Tianjin Medical University, Tianjin First Center Hospital

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337

OpenAlex ID: W4413471652

FWCI: 3.038

Cites:

Cited by: 5

Related to: 10