Work

Latent class analysis of inflammation and drug-induced liver injury phenotypes in older tuberculosis patients: associations with anxiety, depression, and insomnia

Year: 2025

Type: article

Abstract: Introduction Anxiety, depression, and insomnia are common among older patients with tuberculosis (TB), yet their associations with inflammatory responses and drug-induced liver injury (DILI) remain insufficiently explored. This study aimed to identify distinct inflammation-DILI phenotypes in older TB patients and examine differences in anxiety, depression, and insomnia across subgroups. Methods In this cross-sectional study, 251 older TB patients were evaluated. Serum inflammatory markers and liver function indicators were collected, along with standardized assessments of anxiety, depression, and insomnia. Latent class analysis (LCA) was employed to classify inflammation-DILI phenotypes, and multinomial logistic regression was used to explore associations between subgroup characteristics and mental health outcomes. Results Three latent subgroups were identified: (1) moderate inflammation with normal liver function (83.2%), (2) mild inflammation with abnormal liver function (5.3%), and (3) severe inflammation with normal liver function (11.5%). Compared with the moderate inflammation group, the severe inflammation group exhibited significantly higher rates of anxiety, depression, and insomnia. Alcohol consumption was a significant risk factor for severe inflammation (P < 0.05), while smoking was associated with mild inflammation and abnormal liver function (P < 0.05). Conclusion Distinct inflammation-DILI phenotypes exist among older TB patients and are associated with varying psychological symptom burdens. Monitoring inflammatory markers, liver function, and mental health symptoms—especially insomnia, anxiety, and depression—may facilitate more personalized care in this vulnerable population.

Source: Frontiers in Psychiatry

DOI: 10.3389/fpsyt.2025.1607551

Authors: Dan Lei, Quanxian Liu, Qiong He, Zhongmin Fu

Institution: Zunyi Medical University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801