Work

Intestinal aging-related immune dysfunction: mechanisms and interventions

Year: 2025

Type: article

Abstract: Intestinal immunosenescence, a hallmark of organismal aging, has emerged as a critical biological process impacting the health of elderly individuals. This review systematically examines the core mechanisms underlying intestinal immunosenescence, including immune cell dysfunction, imbalances in immune-microbiota interactions, and impaired barrier function. We analyze its associations with infectious diseases, chronic inflammation, and neurodegenerative disorders, summarizing recent advances in dietary interventions, microecological therapy, and other emerging strategies. By integrating cutting-edge technologies, we prospect the development of precision interventions aimed at delaying intestinal immunosenescence, thereby providing a theoretical basis for improving the healthspan of the aging population.

Source: Acta Biochimica et Biophysica Sinica

DOI: 10.3724/abbs.2025157

Authors: Xin Shen, Xianzhi Gao, Lie Wang

Institutions: Zhejiang University, First Affiliated Hospital Zhejiang University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities