Year: 2025
Type: article
Abstract: Perinatal insults (e.g., obstetric complications, substance exposure) are increasing in prevalence and confer risk for psychotic-like experiences in offspring, contributing to a growing public health burden. Perinatal insults often co-occur, creating methodological challenges in understanding their impacts on psychosis-spectrum phenotypes. Data-driven approaches to organizing perinatal insults and testing their longitudinal effects on psychotic-like experiences in youth increases ecological validity and translational utility. Using data from 11,417 youth ages 9-14 across five years of the Adolescent Brain Cognitive Development (ABCD) Study, data-driven dimensions of perinatal insults were derived through exploratory factor analysis of thirty-one perinatal insults. Latent growth modeling tested the effect of perinatal insult dimensions on trajectories (baseline, rate-of-change, year-four severity) of distressing psychotic-like experiences. Six dimensions of perinatal insults were observed (substance exposure, obstetric complications, birth complications, postnatal challenges, parental age, medical needs). Substance exposure (β = 0.42, 95% CI [0.20, 0.63]), obstetric complications (β = 0.34, 95% CI [0.08, 0.61]), and parental age (β = 1.00, 95% CI [0.76, 1.22]) were associated with elevated baseline psychotic-like experiences. Perinatal insult dimensions were not associated with increasing rates-of-change in psychotic-like experiences. Medical needs (β = -0.12, 95% CI [-0.20, -0.05]) and parental age (β = -0.11, 95% CI [-0.18, -0.03]) were associated with steeper declines in psychotic-like experiences. Perinatal insult dimensions remained associated with elevated psychotic-like experiences at year-four. Data-driven dimensions of perinatal insults are associated with stably elevated psychotic-like experience trajectories across early adolescence. Given the role of psychotic-like experiences in later psychopathology and functioning, early identification of at-risk offspring is critical in reducing the public health burden of these exposures.
Source: Schizophrenia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,890
Awards: G1020259976, G1058358382, G1436251778, G1510635755, G1569016918, G1586463187, G1742849658, G2651839268, G2715786902, G2735337927, G2998093352, G3305455594, G343603955, G3438786812, G3563224455, G3613235854, G3738900353, G3755973507, G3806887440, G4066048162, G4161528904, G4180929035, G4241744443, G4645144506, G469525291, G5002640097, G5081895789, G5139799579, G5976565686, Longitudinal Assessment of Distinct Motor Learning Processes to Inform Mechanistic Models of Sensorimotor Function in Psychosis, G687916792, G6887863799, G6922259526, G6983123888, G7271102572, G7652160222, G771167098, G815084465, Training in Clinical Translational Science: Maximizing the Public Health Impact, G8679417706, G9000006386, G9000008241, G9000034221, G9000042425, G9000046731, G9000061868, G9000108491, G9000112882, G9000113866, G9000163168, G9000189140, G9000205938, G9000241459, G9000241758, G9000286149, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, 17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, 21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTL, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB, G923039674
OpenAlex ID: W4413489753