Stachyose alleviates coronary heart disease by modulating the metabolic pathways influenced by gut microbiota and short-chain fatty acids
Year: 2025
Type: article
Abstract: Salvia miltiorrhiza polysaccharide (SMP), primarily composed of stachyose, plays a significant role in treating coronary heart disease (CHD). This study aimed to investigate the effects of stachyose on alleviating CHD through physiological, microbiomic, and metabolomic analyses. Both stachyose and SMP reduced blood viscosity, mitigated cardiac injury, and improved intestinal barrier function in CHD rats. Stachyose supplementation significantly remodeled the gut microbiota, leading to an increased abundance of beneficial bacteria. The results demonstrated that stachyose effectively enhanced butyric acid levels, elevated the concentration of short-chain fatty acids, and modulated five metabolic pathways. In particular, stachyose significantly restored the levels of indole derivatives by promoting tryptophan metabolism, which positively correlated with beneficial bacteria such as Bifidobacterium and Ruminococcus . Collectively, these results suggested that stachyose could serve as a functional food for alleviating CHD.
Authors: Tingting Tang, Liyuan Yang, Haoran Liu, Xiangcheng Fan, Huijun Wang, Xia Tao, Feng Zhang, Wansheng Chen
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,530
OpenAlex ID: W4413509469