Work

Association of renal function with cognitive progression in de novo Parkinson’s disease

Year: 2025

Type: article

Abstract: BACKGROUND: People with chronic kidney disease (CKD) who had decreased renal function were more likely to develop cognitive decline in contrast to the general population. OBJECTIVE: Whether renal function parameters can effectively predict cognitive progress in Parkinson's disease is not yet clear. METHODS: In the present study, 612 de novo Parkinson's Disease (PD) patients from the Parkinson's Progression Markers Initiative (PPMI) database were recruited. To examine the associations between renal function parameters and cognition we utilized multiple linear regression models and mixed-effects models. Cox regression was used to investigate whether the renal function parameters were the risk factors for developing dementia in PD participants. RESULTS: Regression analyses indicated that creatinine (Cr), blood urea nitrogen (BUN), Blood urea nitrogen / Creatinine ratio (BUN/Cr), and estimated glomerular filtration rate(eGFR) were strongly associated with cognitive score as indicated by global cognition (MoCA, β = 0.066, p = 0.015; β = -0.043, p = 0.025; β = -0.070, p < 0.001; β = -0.058, p = 0.013, respectively). Serum uric acid (SUA) and the serum uric acid / Creatinine ratio (SUA/Cr) were associated with cognitive decline as indicated by executive function/working memory (LNS, β = -0.045, p < 0.001; β = -0.032, p = 0.025, respectively). Higher SUA/Cr and eGFR were associated with a higher incidence of developing PD dementia after an average follow-up of 7.26 ± 2.50 years (HR = 1.014, 95 % CI 1.004 to 1.024, p = 0.006; HR = 1.190, 95 % CI 1.023 to 1.384, p = 0.025, respectively). CONCLUSIONS: Our findings revealed the relationship between renal function and cognition in PD patients, which indicated that renal function might play a role in cognitive progression in de novo Parkinson's.

Source: Journal of Clinical Neuroscience

DOI: 10.1016/j.jocn.2025.111495

Authors: Xuanyue Zhang, Li Cui

Institutions: Dalian Medical University, Yuxian People's Hospital

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,830