Work

Ionic-liquid mediated one-pot synthesis of novel thiazolidinones containing pyrazole and thiazole hybrid as COX-1/COX-2 inhibitor

Year: 2025

Type: article

Abstract: A one-pot, ionic-liquid-mediated synthesis has been developed for novel thiazolidine-4-ones containing a pyrazole and thiazole hybrid. This was achieved using a three-component reaction of 2-amino-thiazole, pyrazole-3-aldehyde, and mercaptoacetic acid in [bmim][PF6]. The whole procedure is robust and straightforward. By employing this protocol, a series of novel thiazolidine-4-ones containing pyrazole and thiazole hybrids were prepared in good yield (56-88%) and their preliminary cyclooxygenase activities were also studied and reported. The compounds 3h and 3k show the top-tier selective index for cyclooxygenase enzyme, in comparable with celecoxib as a standard.

Source: Organic Communications

DOI: 10.25135/acg.oc.193.2506.3564

Authors: Vivek T. Humne, Deekshaputra R. Birhade, Omprakash B. Pawar

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Savitribai Phule Pune University, Science and Engineering Research Board

Awards: G3244836779, G5359784247

OpenAlex ID: W4413525142

FWCI: 0.298

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Cited by: 1

Related to: 10