Work

Catalytic Enantioselective Synthesis of Oxazolines with Vinylogous Isocyano Esters

Year: 2025

Type: article

Abstract: Vinylogous isocyano esters were prepared for the first time. They react with aldehydes to give chiral oxazolines bearing a pendant conjugated ester under synergistic silver/organocatalysis. The reaction is carried out using a bifunctional squaramide in combination with silver oxide and performs well with a number of aryl, heteroaryl, and cycloalkyl aldehydes, providing the expected heterocycles in good yields with good diastereoselectivity and enantiomeric excesses ranging from 60% to 95% ee.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c02729

Authors: Cristian Guzmán-Cedillo, Alicia Monleón-Ventura, Amparo Sanz-Marco, Carlos Vila, Gonzalo Blay

Institution: Universitat de València

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Ministerio de Ciencia, Innovación y Universidades, Generalitat Valenciana, Agencia Estatal de Investigación, European Social Fund