Work

Metastatic cardiac tumor resulting in cardiogenic shock from muscle-invasive urothelial carcinoma of the bladder: a case report

Year: 2025

Type: article

Abstract: Muscle-invasive bladder cancer (MIBC) with cardiac metastasis typically carries a very poor prognosis. A Black woman in her 70s developed high-grade urothelial carcinoma with squamous differentiation invading the bladder muscle. Despite chemotherapy, radiation, and nephrostomy, the disease progressed. Six months after diagnosis, imaging revealed metastases to the heart and liver with biopsy showing a rare p63-positive, CK7-negative phenotype. Following a single dose of pembrolizumab, she died within three weeks, likely from cardiogenic shock. In CK7-negative variant urothelial carcinoma, early cardiac imaging and expanded immunohistochemical panels may improve detection of atypical metastases.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2025.103178

Authors: Logan Wesemann, Brian Thomas, Daniel Kim, Zachariah Taylor, Matthew McCoo, Gregory C. McMahon

Institutions: Rocky Vista University, Main Line Health

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160