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Case Report: A case of sudden death due to occupational nicotine poisoning: clinical presentation and MRI findings

Year: 2025

Type: article

Abstract: Background: Nicotine is a toxic alkaloid commonly found in tobacco products. This paper presents the clinical case of a patient who was exposed to a nicotine-laden waste liquid. Case presentation: A 24-year-old male arrived at a local hospital in a state of coma and cardiac arrest. Following successful cardiopulmonary resuscitation, he was transferred to our facility for further treatment. Magnetic resonance imaging of the patient's head and neck revealed bilateral ischemic infarctions in the hippocampal region. After 24 days of treatment, the patient was discharged with significant improvement. Discussion: This case highlights the potential for severe clinical manifestations to arise shortly after a single exposure to a substantial amount of nicotine. Conclusion: In clinical practice, it is crucial to promptly assess the patient's occupational history to identify the cause of the condition, closely monitor vital signs, and provide active supportive and symptomatic care. Additionally, this case underscores the importance of ensuring production safety and increasing awareness regarding occupational exposure risks.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2025.1567380

Authors: Jianjian Liu, Zhaozhao Shan, Xiangdong Jian, Baotian Kan

Institutions: Shandong University, Qilu Hospital of Shandong University

Language: English

Topic: Poisoning and overdose treatments

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801