Work

Uncoupling protein 3 regulates energy and stress-related pathways in undifferentiated skeletal muscle myoblasts

Year: 2025

Type: article

Abstract: This article provides new information demonstrating that UCP3 plays a role in modulating energy and redox stress-related signaling pathways in proliferative muscle myoblasts. The studies used both UCP3 whole body knockout (KO) myoblasts as well as a novel UCP3 conditional KO mouse generated as part of the current study. Collectively, these findings show that, despite low levels, UCP3 is a key modulator of energy metabolism and oxidative stress in undifferentiated muscle myoblasts.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00366.2025

Authors: Austin Kindall, Yen Huynh, Jeesun Kim, Stefano Tiziani, John DiGiovanni

Institution: The University of Texas at Austin

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases