Work

Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and 124I

Year: 2025

Type: article

Abstract: Purpose Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner. Methods We prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 and 1.44 MBq of 124 I. The samples were scanned in two different setups: once with a couple of centimeters between each sample (15 min scan time) and once with all samples taped together (40 min scan time). For each scan, we determine the oPs lifetime for the full samples and at the voxel level. The voxel sizes under consideration are 10.0 3 mm 3 , 7.1 3 mm 3 and 4.0 3 mm 3 . Results Amberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are 2.52 ± 0.03 ns, 2.37 ± 0.03 ns, 2.27 ± 0.04 ns and 1.82 ± 0.02 ns, respectively. The voxel-wise oPs lifetime fits showed that even with 4.0 3 mm 3 voxels the samples are clearly distinguishable and a central voxels have good count statistics. However, the situation with the samples close together remains challenging with respect to the spatial distinction of regions with different oPs lifetimes. Conclusions Our study shows that positronium lifetime imaging on a commercial LAFOV PET/CT is feasible using 124 I.

Source: EJNMMI Physics

DOI: 10.1186/s40658-025-00790-z