The Synthesis, in vitro Antibacterial, Antifungal biological activities along with In silico Molecular Docking studies of Substituted 2-[4-(3-Oxo-[1,2,4] triazolo[4,3-a]pyridin-2-ylmethyl)-[1,2,3]triazol-1-yl]-N-(4-phenyl-thiazol-2-yl)-acetamide
Year: 2025
Type: article
Abstract: A new series of substituted 2-[4-(3-Oxo-[1,2,4]-triazolo-[4,3-a]pyridin-2-ylmethyl)-[1,2,3]triazol-1-yl]-N-(4-phenyl-thiazol-2-yl)-acetamide compounds are synthesized and evaluated for Antimicrobial activity. Antibacterial activity was performed against bacteria (S. Aureus, S. Pyogenus) as Gram-positive, and (E. Coli, P. Aeruginosa) as Gram-negative bacteria. Antifungal activity was performed against (C. Albicans, A. Niger, and A. Clavatus). In the results compounds selected compounds exhibit significant antibacterial activity in comparison to others. MIC was compared to currently marketed drugs also.
Source: Indian Journal of Chemistry
Authors: Dr. Kaushik Joshi, Sagar Maheta, Dr. Anil Mahida, Gaurang Dubal
Institution: RK University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4413616080