Baseline Patient Profile of ErtuRamadan Study: A Real-world Evaluation of Ertugliflozin
Year: 2025
Type: article
Study design: Observational Study
Abstract: A BSTRACT Background and Objectives: The ErtuRamadan study aimed to evaluate the effectiveness of ertugliflozin in type 2 diabetes mellitus (T2DM) patients observing Ramadan fasting. This article presents the baseline characteristics of enrolled participants. Methods: This real-life experience study was conducted across 15 diabetic care centers in Bangladesh. Adults with T2DM for at least 1 year and with a serum glycated hemoglobin (HbA1c) level of <10% were approached for inclusion, and a total of 1555 patients were enrolled. The enrolled patients were stratified into two groups by the use of ertugliflozin, where the ertu group ( n = 803) consisted of patients receiving ertugliflozin 5 mg (single daily dose) for at least 3 months prior to Ramadan fasting, with or without other oral antidiabetic (OAD) agents. Nonertu group ( n = 752) included patients receiving any OADs other than ertugliflozin. All participants were assessed for glycemic status and other relevant information before the start of Ramadan fasting, followed by a post-Ramadan assessment. Results: The average age of participants was 50.14 ± 11.38 (standard deviation) years, with 45% aged 41–55 years and a female predominance (58.9%). Only 14.9% of participants had optimal glycemic control with a mean HbA1c of 8.10% ± 3%. The mean duration of T2DM was 6.48 ± 5.13 years. Of all, 64.6% of participants were obese, and 18.1% were overweight. Hypertension (66.8%) and dyslipidemia (65.1%) were the most common comorbidities. In addition, hyponatremia and hypokalemia were observed in 8.1% and 7.9% of patients, respectively. Conclusion: The pre-Ramadan glycemic status of the enrolled patients revealed that a significant number of those with T2DM exhibited poor glycemic control.
Authors: Md. Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim
Institutions: Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders, Bangladesh Medical University, Dhaka Medical College and Hospital, Rajshahi Medical College, Sir Salimullah Medical College, Mymensingh Medical College Hospital, North East Medical College, Chattagram Maa-O-Shishu Hospital Medical College, National Institute of Traumatology & Orthopaedic Rehabilitation, Rangpur Medical College
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413619170