Downregulation of the mitochondrial tRNA-derived fragment mt-tRF-Leu TAA enhances skeletal muscle insulin sensitivity
Year: 2025
Type: article
Abstract: Fasting downregulates levels of mt-tRF-Leu TAA in skeletal muscle. While this small RNA fragment is enriched in the mitochondria of myotubes, inhibition of mt-tRF-Leu TAA in myotubes enhances insulin-mediated glucose uptake. Consistently, mt-tRF-Leu TAA is also downregulated in the skeletal muscle of insulin-hypersensitive rats. Together, these findings highlight mt-tRF-Leu TAA as a key metabolic regulator influencing both insulin secretion and action.
Institution: University of Lausanne
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: Non-coding RNAs as regulators of pancreatic beta-cell function and mediators of inflammatory signals in diabetes, Role of tRNA-derived fragments in the control of pancreatic beta-cell functions and in diabetes development, SPRINTING TOWARDS MITOCHONDRIAL FITNESS: Understanding skeletal muscle mitochondrial adaptations to sprint interval training using high-resolution respirometry
OpenAlex ID: W4413636011