Colonic Metastasis of Renal Cell Carcinoma: A Rare Cause of Lower Gastrointestinal Bleeding
Year: 2025
Type: article
Study design: Case Report
Abstract: Renal cell carcinoma (RCC) metastasis to the large bowel is exceptionally rare and can present as lower gastrointestinal bleeding. We report the case of an 80-year-old man who presented to our institution with a history of left-sided RCC and known pulmonary and osseous metastases, who presented with recurrent rectal bleeding and profound anemia. Initial colonoscopy demonstrated an ulcerated splenic-flexure nodule, but biopsies were non-diagnostic. One week later, flexible sigmoidoscopy revealed a friable, actively bleeding rectal lesion; endoscopic polypectomy and hemostatic clips were placed. Histopathology confirmed metastatic RCC. Given his advanced disease and functional status, goals-of-care discussions resulted in the initiation of comfort care. This case underscores the importance of maintaining a broad differential for lower GI bleeding in patients with known RCC, including colonic metastasis. Endoscopic evaluation not only facilitates diagnosis but also provides therapeutic hemostasis. A multidisciplinary approach combining gastroenterology and oncology may help ensure accurate diagnosis, effective management, and alignment of care with patient-centered goals of care.
Source: Cureus
DOI: 10.7759/cureus.91037
Authors: Daniel J Canter, Urmimala Chaudhuri, Chase Thornton, Hassan Zreik, Drew Triplett
Institution: Wright State University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413636118