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First experience of Russian-manufactured generic nusinersen treatment in pediatric SMA patients

Year: 2025

Type: article

Abstract: Currently, Russian-manufactured generic products are being actively implemented into the clinical practice in the Russian Federation, including spinal muscular atrophy treatment. This article presents five clinical cases with various types of spinal muscular atrophy treatment with generic Russian nusinersen, both naive and those who had previously received therapy with the reference drug nusinersen and continued therapy with generic nusinersen. The trend in motor activity in patients during treatment, assessed by motor development scales, is presented. In all of 5 described clinical cases both the positive effect and favorable safety profile of the Russian-manufactured generic nusinersen were demonstrated.

Source: L O Badalyan Neurological Journal

DOI: 10.46563/2686-8997-2025-6-2-105-112

Authors: Lyudmila M. Kuzenkova, Eugeniya V. Uvakina, Eleonora B. Serebrennikova, Ekaterina I. Karpovich, Tatyana A. Samofal, Oleg L. Lapotchkin, Aleksandra A. Smirnova, Anna A. Golenko

Institution: Sechenov University

Language: English

Topic: Neurogenetic and Muscular Disorders Research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413636453

FWCI:

Cites: 3

Cited by:

Related to: 10