Work

Role of intestinal claudin-2 in calcium permeability and whole body calcium balance

Year: 2025

Type: article

Abstract: Global claudin-2 knockout mice have hypercalciuria due to both intestinal overabsorption of calcium and a renal calcium leak. Here, we generated intestine-specific claudin-2 knockout mice. Ileal and colonic calcium permeability were reduced, but surprisingly these animals exhibited only transient hypercalciuria for 1 wk after weaning. Thus, claudin-2 contributes to intestinal permeability to calcium but does not play a significant role in intestinal calcium absorption or secretion.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00133.2025

Authors: Duuamene Nyimanu, Christine Behm, Alan S. L. Yu

Institution: University of Kansas Medical Center

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases