Work

Chronic Pulmonary Complications After COVID-19

Year: 2025

Type: article

Abstract: Background: Long-term pulmonary complications after COVID-19 are increasingly recognized, but few studies have characterized their progression and risk factors over extended follow-up. Research Question: What are the prevalence, progression, and predictors of chronic pulmonary complications in COVID-19 survivors over a 24-month period? Study Design and Methods: We conducted a prospective observational cohort study of 355 adults (20-55 years of age) with polymerase chain reaction-confirmed COVID-19 in Egypt, followed at 6, 12, and 24 months after infection. Assessments included pulmonary function tests, high-resolution CT scan, and standardized symptom questionnaires. Multivariable logistic regression was used to identify independent predictors of interstitial fibrosis and pulmonary embolism (PE). Results: = .001), and more rapid symptom resolution. Interpretation: Most COVID-19 survivors experienced symptomatic and functional improvement over 2 years. However, a substantial subset, particularly those unvaccinated or with severe initial illness, developed progressive interstitial fibrosis and increased risk of PE. Long-term pulmonary surveillance and vaccination may reduce these chronic sequelae.

Source: CHEST Pulmonary

DOI: 10.1016/j.chpulm.2025.100208

Authors: Tarek Mohamed M. Mansour, Ahmed Abd elrady Ahmed teleb, Hytham Abdalla, Mohamad M. Abd elnaser, Mohamed M. El-baroudy, Hossam Abd El-Moez Mohammed

Institutions: Al-Azhar University, Assiut University, Luxor University

Language: English

Topic: Long-Term Effects of COVID-19

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500