P98 | A challenging case of malnutrition
Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction: Malabsorption as a clinical manifestation of gastrointestinal amyloidosis is a possible consequence.Case report: A 55-year-old man presented to the emergency room with recurrent anemia, severe hypoglycemia, and episodes of vomiting. He had a history of renal dysfunction, rheumatoid arthritis, arterial hypertension, and postpolio tetraplegia. In June 2018, he had a right hemicolectomy with ileostomy after an abdominal CT revealed ischemic colitis. Histological investigation revealed ischemic hemorrhagic infarction with amyloidosis. In May 2023, because of his continuous severe anemia, he had a bone marrow biopsy, which revealed periosteal soft tissue with amyloid deposits. Upon arrival, the patient appeared dehydrated and with normal vital signs. The blood test revealed acute renal failure, including normal electrolytes, leukocytosis, platelets, and elevated CRP. The main complication reported was severe hypoglycemia caused by prolonged malnutrition in the presence of systemic and gastrointestinal amyloidosis, which was treated with glucose and NPT infusions. The blood test and clinical picture of acute pulmonary subedema indicated a worsening of cardiac contractility, so he underwent an echocardiogram, which revealed septal hypertrophy (SIVd 20 mm and SIVs 21 mm) and posterior wall (PPd 19 mm and PPs 20 mm) with low systolic function indices (EF 25%). After approximately 20 days in the hospital, the patient died from heart failure and multiple organ failure.Conclusions: The prognosis for patients with systemic amyloidosis is usually poor.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4413638774