Year: 2025
Type: article
Abstract: A GTPase regulatory protein, PXF-1, is required for synapse development through an actin-mediated mechanism in Caenorhabditis elegans. In this work, Salvatore Cherra and colleagues show that two conserved guanine exchange factors are activated downstream of PXF-1 in a signalling pathway that promotes cholinergic synapse formation in C. elegans. To find out more about their work, we spoke to the first author, Reagan Lamb, and the corresponding author, Salvatore Cherra, Assistant Professor, Department of Neuroscience, College of Medicine, University of Kentucky, USA.
Source: Development
DOI: 10.1242/dev.205151
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4413641472