Work

Kras and ciliary gene mutations cooperatively lead to pancreatic tumorigenesis only when induced during embryogenesis

Year: 2025

Type: article

Abstract: Mutations in the Kras oncogene are present in approximately 25% of tumors, while defective primary cilium can either promote or suppress specific cancer types. In the present study, we investigated whether mutations in Kras and genes important for primary cilium formation could collaboratively contribute to pancreatic cancer. Using mouse models, we found the presence of collaboration when these mutations were induced in the pancreas during embryogenesis, whereas no collaboration was observed when they were induced after birth. These results help to understand why mutations in ciliary genes do not appear in the mutational landscape of human pancreatic cancer.

Source: Scientific Reports

DOI: 10.1038/s41598-025-16682-2

Authors: Angeline Fages, Memoona Rajput, Christine Sempoux, Patrick Jacquemin

Institutions: de Duve Institute, UCLouvain, Centre Hospitalier Universitaire Vaudois, University of Lausanne

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690