P86 | Active surveillance: what changed?
Year: 2025
Type: article
Abstract: Background: Active surveillance programs aim to prevent the spread of carbapenemase-producing Enterobacterales (CPE). Rectal swab (RS) is used for screening colonized subjects. The samples are analyzed from January 2020 to November 2023 in the Ospedale del mare Clinical Pathology Unit bacteriology. Our focus is on the RS received from Non-Intensive Area (NIA) and Intensive Area (IA).Design: The protocol involves sowing on KIT CARBA chromogenic medium and on MacConkey Agar with meropenem disk. The XpertCarba-R assay is carried out on positive samples to differentiate the carbapenemase gene. Then the identification and the antibiogram are done with the automatic Vitek2 system.Results: 7350 RS processed with 366 positive results, 80% positive for KPC, 6.28% for NDM, 3.55% for VIM, 3% for OXA48, 6.28% for 2 carbapenemase genes, 2.73% KPC+NDM, 1.91% KPC+OXA48, 1.36% KPC+ VIM, 0.27% OXA48+VIM. K. pneumoniae was found most frequently (337), follewed by E. coli (20). RS are performed on entry end than once a week in IA, while only once in NIA.Conclusions: Our data show an increase in positive tests from 2020 to 2023 of 0.08% for IA and 60% for NIA. KPC was most detected resistance mechanism, but NDM, OXA48 and VIM increase. Hospital circulation of resistance mechanism leads to highest positive RS for KPC in IA. Instead, data can offer a picture of a territorial miltiresistance pathogens due to screening or to abuse of antibiotic therapy in NIA. In conclusion, rapid results with the related resistance mechanism is critical for decisions making.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4413656026