Year: 2025
Type: article
Study design: Case Report
Abstract: Ibuprofen is a widely used and easily accessible medication that belongs to the nonsteroidal anti-inflammatory drug class. Its most common adverse effects are gastrointestinal. However, there are a few reported cases of fatal side effects. We report a case of toxic epidermal necrolysis (TEN) potentially affecting more than 80% of the total body surface area, triggered by ibuprofen in a 77-year-old female patient after taking it for the first time. The diagnosis of TEN was confirmed through skin biopsy. The severe mucocutaneous reactions, Stevens-Johnson syndrome and toxic epidermal necrolysis, are characterized by necrosis and skin sloughing. Both share the same pathophysiology; however, they differ based on the total body surface area affected. Toxic epidermal necrolysis is defined as an affected body surface area greater than 30%, so early diagnosis and identification of the cause are crucial to determine its course and prognosis.
Source: Cureus
DOI: 10.7759/cureus.91001
Authors: Esperanza Vanessa Matadamas Carmona, Marco Antonio Jimenez Ferreira
Institution: Secretaria de Salud
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413670503