Work

The serum levels and clinical significance of ferroptosis markers in patients with aneurysmal subarachnoid hemorrhage who underwent aneurysm clipping surgery

Year: 2025

Type: article

Abstract: OBJECTIVE: This study aimed to explore the association between ferroptosis markers and postoperative prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH) who underwent aneurysm clipping. Specifically, we evaluated the predictive value of ferroptosis markers in determining post-operative outcomes. METHODS: We conducted a prospective observational study involving 210 aSAH patients who underwent aneurysm clipping surgery at our institution from October 2021 to May 2023. Blood samples were collected at postoperative days 1, 3, 7, and 30 to assess the levels of ferroptosis markers (ACSL4, SLC7A11, GPX4) and inflammatory cytokines (CRP, IL-6, TNF-α) using enzyme-linked immunosorbent assay (ELISA). Clinical data were recorded at baseline. Postoperative prognosis was assessed using the modified Rankin Scale (mRS) at 30 days post-surgery. All patients included in the study underwent aneurysm clipping surgery as their primary treatment modality. RESULTS: The serum levels of ACSL4 and IL-6 were significantly higher in the mRS 3-6 group compared to the mRS 0-2 group at all time points. In contrast, SLC7A11 and GPX4 levels were significantly lower in the mRS 3-6 group. Spearman's correlation analysis revealed a significant negative correlation between ACSL4 and GPX4 and a positive correlation between ACSL4 and IL-6 levels. ROC curve analysis demonstrated that ACSL4 had the highest predictive value for poor postoperative prognosis, with an area under the curve (AUC) of 0.757. Multivariate logistic regression analysis identified aneurysm size, GCS, SLC7A11, ACSL4, GPX4, and IL-6 as independent risk factors for poor postoperative prognosis. CONCLUSION: Serum ferroptosis markers, particularly ACSL4, along with inflammatory markers, have significant potential in predicting the postoperative prognosis of aSAH patients. These markers could serve as useful biomarkers for early risk stratification and clinical decision-making in aSAH management.

Source: Journal of Stroke and Cerebrovascular Diseases

DOI: 10.1016/j.jstrokecerebrovasdis.2025.108440

Authors: Xiaoli Wu, Xiqi Hu, Ying Xia, Bo Wang

Institution: Central South University

Language: English

Topic: Intracranial Aneurysms: Treatment and Complications

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,170