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Recent Advances in Application of Circularly Polarized Luminescence Probes toward Bioimaging Technology

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Circularly polarized luminescence (CPL) refers to the differential emission of left- and right-handed circularly polarized light in chiral materials, exhibiting significant potential for applications in bioimaging. The introduction of CPL can effectively eliminate the background autofluorescence interference, thereby enhancing the signal-to-noise ratio and resolution. Furthermore, CPL probes serve as robust detection tools capable of directly identifying the unique optical fingerprint information on the chiral targets, enabling real-time dynamic tracking of species within organisms, thus facilitating higher-dimensional bioimaging. Recently, a new series of CPL probes has been developed for cellular and in vivo imaging. This review summarizes the research progress of various CPL probes designed for efficient bioimaging, including CPL-active lanthanide metal complexes, small molecules, and nanomaterials. Finally, we discuss the current challenges and future prospects of these CPL probes in the field of bioimaging.

Source: Chemical & Biomedical Imaging

DOI: 10.1021/cbmi.5c00091

Authors: Dong Li, Zhenhao Jiang, Xinyu Liu, Yixiang Cheng

Institutions: State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: diamond

Funder: National Natural Science Foundation of China

Awards: G3457854553, G7620915198