Work

Granular acute lymphocytic leukemia : a case report and literature review

Year: 2025

Type: article

Abstract: Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by the clonal proliferation of precursor lymphoblasts in the bone marrow. Granular acute lymphoblastic leukemia (G-ALL) is a rare subtype of ALL, primarily associated with B-cell lineage. Traditionally, cytoplasmic granules indicate myeloid leukemia cell differentiation, as primitive lymphoblasts typically lack cytoplasmic granules. Therefore, the immature lymphoblasts in G-ALL may be mistaken for granular myeloid progenitor cells, causing potential diagnostic errors. The involvement of the BCOR gene in acute lymphoblastic leukemia has not been well-documented. This study examines the clinical data of a G-ALL patient, reviews relevant literature, and aims to improve disease recognition among clinicians and laboratory personnel, enhance diagnostic accuracy, and reduce instances of misdiagnosis and mistreatment.

Source: Discover Oncology

DOI: 10.1007/s12672-025-03449-4

Authors: Yike Tian, Ping Huang, Mi Jiang, Jing Wu, Wei Cai

Institutions: Chongqing Medical University, The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690