P71 | Cardiovascular effects of Bruton’s tyrosine kinase inhibitor in chronic lymphocytic leukemia: an advanced echocardiographic study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Bruton’s tyrosine kinase (BTK) inhibitors have revolutionized treatment of chronic lymphocytic leukemia (CLL). However, ibrutinib, the first BTK inhibitor approved, is associated with serious toxicities including atrial fibrillation, ventricular arrhythmias, hypertension and heart failure.Objectives: Aim of the study is to monitor cardiac performance of patients with CLL treated with Ibrutinib using advanced echocardiography during a six-months follow-up.Methods: Study population includes 26 patients who, before starting treatment and six months later, underwent standard and advanced echocardiographic evaluation including left ventricular global longitudinal strain (GLS), left atrial strain and myocardial work study: global work index (GWI), constructive work (GCW), wasted work (GWW) and work efficiency (GWE).Results: At follow up evaluation there weren’t statistically significant differences of standard and advanced echocardiographic parameters evaluated, although two patients have developed atrial fibrillation.Conclusions: The stability of myocardial work parameters with improvement of myocardial efficiency (91.57 vs. 90.42) although not significant, allows us to hypothesize a potential beneficial effect of increased blood pressure on cardiac performance. The stability of the echocardiographic parameters of atrial strain allows us to hypothesize that Ibrutinib doesn’t worsen atrial remodeling, therefore it may not be necessary to interrupt this life-saving therapy, while the basal stratification of the patients before starting treatment remaining fundamental.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413686464