P76 | Diarrhea in lung transplant recipient
Year: 2025
Type: article
Study design: Case Report
Abstract: Premises: Diarrhoea is defined as reduced stool consistency, increased water content and number of evacuations per day. The causes of diarrhoea can be multiple: many different infectious agents, drugs, inflammatory diseases, autoimmune diseases. Description of the Case report: A 62-year-old man has been hospitalized for diarrhea for three weeks: 6-7 discharges of watery diarrhea per day. He reports loss of appetite, reduced water intake and weight loss. In the patient’s medical history, he received a lung transplant for idiopathic pulmonary fibrosis 3 years ago. The patient’s immunosuppressive therapy was mycophenolate and tacrolimus, and he was on prophylaxis with cotrimoxazole and azithromycin. Blood tests showed acute renal failure with mild hypokalemia, negative inflammation indices. He was evaluated for bacteria, viruses, and parasites with negative results. There was a rapid normalization of renal function with hydration therapy, but persistence of diarrhea. The screening for celiac disease was negative, and thyroid function was normal. The colonoscopy was normal. In the suspicion of microscopic colitis, therapy with budesonide was started with resolution of the diarrhea. Histological examination confirmed the suspicion of microscopic colitis. Conclusions: To solve the clinical case, we proceeded step by step. Infections were excluded and we believed that it could be a microscopic colitis and we started therapy with budesonide with an excellent clinical response. We asked if there was an association between idiopathic pulmonary fibrosis and microscopic colitis.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Topic: Microscopic Colitis
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413686497